- S. Darko ( 2009 ) Crime, Mystery, Science Fiction, Thriller
- Sabotage ( 1936 ) Mystery, Thriller
- Sahara ( 2005 ) Action, Adventure, Comedy, Drama, Mystery
- Salem's Lot ( 1979 ) Horror, Mystery, Thriller
- Salem's Lot ( 2004 ) Drama, Horror, Mystery, Thriller
- Salt ( 2010 ) Action, Mystery, Thriller
- Salton Sea ( 2002 ) Crime, Drama, Mystery, Thriller
- Sam Was Here ( 2016 ) Horror, Mystery, Thriller
- Sandra ( 1965 ) Drama, Mystery, War
- Santa Sangre ( 1989 ) Fantasy, Horror, Mystery
- Sapphire ( 1959 ) Crime, Drama, Mystery, Thriller
- Sartana the Gravedigger ( 1969 ) Mystery, Western
- Sasquatch, the Legend of Bigfoot ( 1976 ) Adventure, Documentary, Mystery
- Satan Met a Lady ( 1936 ) Comedy, Drama, Mystery
- Satan's School For Girls ( 1973 ) Horror, Mystery
- Savageland ( 2017 ) Horror, Mystery
- Save Me ( 1994 ) Mystery, Thriller
- Saw ( 2004 ) Crime, Horror, Mystery
- Saw VI ( 2009 ) Horror, Mystery
- Say Nothing ( 2001 ) Action, Drama, Mystery, Romance, Science Fiction, Thriller
- Schizo ( 1976 ) Drama, Horror, Mystery, Thriller
- Schizoid ( 1980 ) Horror, Mystery
- Scooby-Doo 2: Monsters Unleashed ( 2004 ) Adventure, Comedy, Fantasy, Mystery
- Scooby-Doo ( 2002 ) Adventure, Comedy, Mystery
- Scooby-Doo! Abracadabra-Doo ( 2010 ) Animation, Comedy, Family, Mystery
- Scooby-Doo! and the Cyber Chase ( 2001 ) Animation, Comedy, Family, Mystery, Science Fiction
- Scooby-Doo! and the Monster of Mexico ( 2003 ) Animation, Comedy, Family, Mystery
- Scooby-Doo! and the Reluctant Werewolf ( 1988 ) Animation, Comedy, Family, Mystery, TV Movie
- Scooby-Doo! Curse of the Lake Monster ( 2010 ) Adventure, Comedy, Fantasy, Mystery
- Scooby-Doo! Frankencreepy ( 2014 ) Animation, Family, Mystery
- Scooby-Doo! Legend of the Phantosaur ( 2011 ) Animation, Family, Mystery
- Scooby-Doo! Music of the Vampire ( 2012 ) Animation, Family, Mystery
- Scooby-Doo on Zombie Island ( 1998 ) Animation, Comedy, Family, Mystery
- Scooby-Doo! Pirates Ahoy! ( 2006 ) Animation, Comedy, Family, Mystery
- Scooby-Doo! The Mystery Begins ( 2009 ) Animation, Comedy, Fantasy, Mystery
- Scooby-Doo! WrestleMania Mystery ( 2014 ) Animation, Comedy, Family, Mystery
- Scoop ( 2006 ) Comedy, Mystery
- Scoop! ( 2016 ) Mystery
- Scourge ( 2008 ) Drama, Horror, Mystery, Science Fiction
- Scream ( 1996 ) Crime, Horror, Mystery
- Scream 2 ( 1997 ) Horror, Mystery
- Scream 3 ( 2000 ) Horror, Mystery
- Scream 4 ( 2011 ) Horror, Mystery
- Scream, Pretty Peggy ( 1973 ) Drama, Horror, Mystery, Thriller, TV Movie
- Se7en ( 1995 ) Crime, Mystery, Thriller
- Sea of Love ( 1989 ) Crime, Drama, Mystery
- Second Nature ( 2003 ) Action, Drama, Mystery, Science Fiction, Thriller, War
- Seconds ( 1966 ) Drama, Mystery, Science Fiction, Thriller
- Secret in Their Eyes ( 2015 ) Crime, Drama, Mystery
- Secret of the Blackbirds ( 1983 ) Mystery, Thriller
- Secret Society of Souptown ( 2015 ) Adventure, Family, Fantasy, Mystery
- Secret Window ( 2004 ) Mystery, Thriller
- Secrets of Eden ( 2012 ) Drama, Mystery, Thriller, TV Movie
- Secrets of the Summer House ( 2008 ) Drama, Horror, Mystery, Thriller
- See No Evil ( 1971 ) Crime, Mystery, Thriller
- Self/less ( 2015 ) Mystery, Science Fiction, Thriller
- Senn ( 2013 ) Adventure, Mystery, Science Fiction
- Sennentuntschi ( 2010 ) Horror, Mystery, Thriller
- Septien ( 2011 ) Comedy, Drama, Mystery
- Session 9 ( 2001 ) Horror, Mystery
- Seven Blood-Stained Orchids ( 1972 ) Crime, Horror, Mystery
- Seven Dead in the Cat's Eye ( 1973 ) Crime, Horror, Mystery, Thriller
- Seventh Code ( 2013 ) Mystery, Thriller
- Severed Footage ( 2013 ) Horror, Mystery, Thriller
- Sexy Evil Genius ( 2013 ) Comedy, Drama, Mystery
- Sh! The Octopus ( 1937 ) Comedy, Mystery
- Shadow of the Blair Witch ( 2000 ) Horror, Mystery
- Shadow of the Thin Man ( 1941 ) Comedy, Mystery, Romance, Thriller
- Shadows ( 2007 ) Drama, Horror, Mystery, Thriller
- Shadows Over Chinatown ( 1946 ) Comedy, Crime, Mystery, Thriller
- Shaft in Africa ( 1973 ) Action, Adventure, Crime, Mystery, Thriller
- Shaft's Big Score! ( 1972 ) Action, Adventure, Crime, Mystery
- Shame the Devil ( 2013 ) Crime, Mystery, Thriller
- Shamus ( 1973 ) Mystery, Thriller
- Shanghai ( 2010 ) Drama, Mystery, Romance
- Shark Skin Man and Peach Hip Girl ( 1998 ) Action, Comedy, Mystery, Thriller
- Shattered ( 1991 ) Mystery, Thriller
- She-Wolf of London ( 1946 ) Crime, Horror, Mystery
- Shelter ( 2010 ) Horror, Mystery, Thriller
- Sherlock Holmes ( 1916 ) Drama, Mystery
- Sherlock Holmes ( 1922 ) Drama, Mystery, Thriller
- Sherlock Holmes ( 2009 ) Action, Adventure, Crime, Mystery
- Sherlock Holmes ( 2010 ) Action, Drama, Fantasy, Horror, Mystery, Thriller
- Sherlock Holmes: A Game of Shadows ( 2011 ) Action, Adventure, Crime, Mystery
- Sherlock Holmes and the Leading Lady ( 1991 ) Crime, Drama, Mystery
- Sherlock Holmes and the Masks of Death ( 1984 ) Mystery
- Sherlock Holmes and the Secret Weapon ( 1942 ) Action, Adventure, Crime, Drama, Mystery, Thriller
- Sherlock Holmes and the Voice of Terror ( 1942 ) Drama, Mystery, Thriller
- Sherlock Holmes Faces Death ( 1943 ) Drama, Mystery, Thriller
- Sherlock Holmes in Washington ( 1943 ) Action, Drama, Mystery, Thriller
- Sherlock Holmes: The Hound of the Baskervilles ( 1988 ) Comedy, Drama, Mystery, Thriller
- Sherlock, Jr. ( 1924 ) Comedy, Drama, Fantasy, Mystery
- Shimmer Lake ( 2017 ) Crime, Drama, Mystery, Thriller
- Shock Corridor ( 1963 ) Drama, Mystery, Thriller
- Shock Treatment ( 1973 ) Crime, Drama, Horror, Mystery, Science Fiction, Thriller
- Shooter ( 2007 ) Action, Crime, Drama, Mystery, Thriller
- Short Night of Glass Dolls ( 1971 ) Horror, Mystery, Thriller
- Short Stories ( 2012 ) Comedy, Drama, Mystery
- Shuffle ( 2012 ) Mystery, Romance, Thriller
- Shutter ( 2004 ) Fantasy, Horror, Mystery, Thriller
- Shutter ( 2008 ) Horror, Mystery, Thriller
- Shutter Island ( 2010 ) Drama, Mystery, Thriller
- Sicario ( 2015 ) Action, Crime, Drama, Mystery, Thriller
- Siddhartha ( 1972 ) Drama, Mystery
- Signs ( 2002 ) Drama, Mystery, Science Fiction, Thriller
- Silent Fall ( 1994 ) Drama, Mystery, Thriller
- Silent Hill ( 2006 ) Horror, Mystery
- Silent Hill: Revelation 3D ( 2012 ) Horror, Mystery, Thriller
- Silent House ( 2011 ) Horror, Mystery
- Silent Night ( 2012 ) Comedy, Horror, Mystery, Thriller
- Silent Retreat ( 2013 ) Horror, Mystery, Thriller
- Silent Retreat ( 2016 ) Horror, Mystery, Thriller
- Silk ( 2006 ) Drama, Horror, Mystery, Science Fiction, Thriller
- Silver City ( 2004 ) Comedy, Drama, Mystery, Thriller
- Sinister ( 2012 ) Horror, Mystery, Thriller
- Sisters ( 2006 ) Horror, Mystery, Thriller
- Site Unseen: An Emma Fielding Mystery ( 2017 ) Mystery
- Six Degrees of Separation ( 1993 ) Comedy, Drama, Mystery
- Skeletons ( 2010 ) Comedy, Fantasy, Foreign, Mystery, Thriller
- Skew ( 2011 ) Horror, Mystery, Thriller
- Skinwalkers ( 2002 ) Crime, Drama, Mystery, Thriller
- Sky Captain and the World of Tomorrow ( 2004 ) Action, Adventure, Mystery, Science Fiction, Thriller
- Sky Murder ( 1940 ) Mystery
- Slam Dance ( 1987 ) Mystery, Thriller
- Slaughter Hotel ( 1971 ) Horror, Mystery, Thriller
- Slaughter of the Innocents ( 1993 ) Action, Horror, Mystery, Thriller
- Sleep, My Love ( 1948 ) Drama, Mystery
- Sleepless ( 2001 ) Crime, Horror, Mystery, Thriller
- Sleepy Hollow ( 1999 ) Drama, Fantasy, Mystery, Thriller
- Sleuth ( 1972 ) Mystery, Thriller
- Slow Burn ( 2000 ) Action, Drama, Mystery, Thriller
- Slow Burn ( 2005 ) Crime, Drama, Mystery, Thriller
- Small Island ( 2009 ) Drama, Mystery, Thriller
- Smilla's Sense of Snow ( 1997 ) Action, Crime, Drama, Mystery, Thriller
- Snake Eyes ( 1998 ) Crime, Mystery
- Snapdragon ( 1993 ) Mystery, Romance, Thriller
- So Dark the Night ( 1946 ) Drama, Mystery
- So Sweet, So Dead ( 1972 ) Crime, Drama, Horror, Mystery, Romance, Thriller
- So Sweet... So Perverse ( 1969 ) Crime, Mystery, Thriller
- Social Nightmare ( 2013 ) Drama, Mystery, TV Movie
- Socialphobia ( 2015 ) Drama, Mystery, Thriller
- Solace ( 2015 ) Crime, Drama, Mystery
- Solaris ( 1972 ) Adventure, Drama, Mystery, Science Fiction
- Solaris ( 2002 ) Drama, Mystery, Romance, Science Fiction
- Solitary ( 2009 ) Mystery, Thriller
- Somebody Killed Her Husband ( 1978 ) Comedy, Crime, Mystery
- Someone's Watching Me! ( 1978 ) Horror, Mystery, Thriller, TV Movie
- Something Wicked ( 2014 ) Mystery, Thriller
- Something Wicked This Way Comes ( 1983 ) Fantasy, Mystery, Thriller
- Somewhere in the Night ( 1946 ) Crime, Drama, Mystery, Thriller
- Sommersby ( 1993 ) Drama, Mystery, Romance, Thriller
- Song of the Thin Man ( 1947 ) Comedy, Crime, Drama, Mystery, Thriller
- Sorority Row ( 2009 ) Horror, Mystery, Thriller
- Sorry for the Disturbance ( 2008 ) Comedy, Drama, Mystery
- Soul Assassin ( 2001 ) Action, Mystery, Thriller
- Soul Survivors ( 2001 ) Horror, Mystery, Thriller
- Soulmate ( 2013 ) Horror, Mystery
- Sound of My Voice ( 2011 ) Drama, Mystery, Science Fiction
- Source Code ( 2011 ) Mystery, Science Fiction, Thriller
- Soylent Green ( 1973 ) Mystery, Science Fiction, Thriller
- Spartan ( 2004 ) Action, Crime, Drama, Mystery, Thriller
- Spasmo ( 1974 ) Mystery, Thriller
- Special Section ( 1975 ) Drama, History, Mystery, War
- Spellbound ( 1945 ) Drama, Mystery, Thriller
- Spellcaster ( 1992 ) Horror, Mystery
- Sphinx ( 1981 ) Adventure, Mystery, Thriller
- Spider ( 2002 ) Drama, Mystery, Thriller
- Spider Forest ( 2004 ) Drama, Foreign, Horror, Mystery, Thriller
- Spiral ( 2000 ) Fantasy, Horror, Mystery
- Spirits of the Dead ( 1968 ) Drama, Horror, Mystery
- Splatter University ( 1984 ) Horror, Mystery, Thriller
- Spooky House ( 2004 ) Adventure, Family, Mystery
- Spoor ( 2017 ) Crime, Drama, Mystery, Thriller
- St. Ives ( 1976 ) Action, Crime, Mystery, Thriller
- Star of Midnight ( 1935 ) Comedy, Mystery, Romance
- Star Trek: The Motion Picture ( 1979 ) Adventure, Mystery, Science Fiction
- Static ( 2012 ) Drama, Horror, Mystery, Thriller
- Station West ( 1948 ) Action, Mystery, Romance, Western
- Stay ( 2005 ) Drama, Mystery, Thriller
- Steel Cold Winter ( 2013 ) Mystery, Thriller
- Step By Step ( 1946 ) Crime, Drama, Mystery, Thriller
- Stille Nacht I ( 1988 ) Animation, Mystery
- Stingray ( 1985 ) Crime, Mystery, TV Movie
- Stir of Echoes ( 1999 ) Horror, Mystery, Thriller
- Stolen ( 2009 ) Crime, Drama, Mystery, Thriller
- Stolen Identity ( 1953 ) Action, Crime, Drama, Mystery, Thriller
- Storm ( 2009 ) Drama, Foreign, Mystery, Thriller
- Storyville ( 1992 ) Drama, Mystery
- Straight on Till Morning ( 1972 ) Mystery, Thriller
- Strange Bargain ( 1949 ) Mystery, Thriller
- Strange Circus ( 2005 ) Drama, Horror, Mystery, Thriller
- Strange Invaders ( 1983 ) Horror, Mystery, Science Fiction
- Strangers in the Night ( 1944 ) Crime, Drama, Mystery
- Stratosphere Girl ( 2004 ) Drama, Foreign, Mystery, Thriller
- Straw Dogs ( 1971 ) Crime, Drama, Mystery, Thriller
- Striking Distance ( 1993 ) Action, Crime, Mystery, Thriller
- Stuck ( 2007 ) Crime, Horror, Mystery, Thriller
- Student Bodies ( 1981 ) Comedy, Horror, Mystery
- Stunts ( 1977 ) Action, Drama, Mystery, Thriller
- Styria ( 2013 ) Fantasy, Horror, Mystery, Thriller
- Such Good People ( 2014 ) Comedy, Mystery
- Suddenly, Last Summer ( 1959 ) Drama, Mystery, Thriller
- Sun Choke ( 2015 ) Drama, Mystery, Thriller
- Sun Don't Shine ( 2012 ) Crime, Drama, Mystery, Romance
- Sunset ( 1988 ) Action, Comedy, Crime, Mystery, Thriller
- Super 8 ( 2011 ) Mystery, Science Fiction, Thriller
- Super Troopers ( 2001 ) Comedy, Crime, Mystery
- Supernatural ( 1933 ) Horror, Mystery, Thriller
- Surveillance ( 2008 ) Horror, Mystery, Thriller
- Survive Style 5+ ( 2004 ) Comedy, Drama, Horror, Mystery
- Susie Q ( 1996 ) Comedy, Drama, Family, Mystery, TV Movie
- Suspect X ( 2008 ) Crime, Drama, Mystery, Thriller
- Suspicion ( 1941 ) Mystery, Thriller
- Svart Lucia ( 1992 ) Drama, Mystery
- Swamp Water ( 1941 ) Crime, Drama, Mystery, Thriller
- Sweet Movie ( 1974 ) Comedy, Drama, Mystery
- Switchback ( 1997 ) Action, Adventure, Mystery, Thriller
- Symphony No. 42 ( 2014 ) Animation, Mystery
- Synchronicity ( 2015 ) Mystery, Science Fiction, Thriller
- Szamanka ( 1996 ) Drama, Horror, Mystery
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